发明名称 |
TEMPERATUREMPFINDLICHE POLYMERE |
摘要 |
The present invention relates to compositions comprising polymers whose solubility characteristics can be changed by incubation and particularly ploy (hydroxyalkyl (meth) acrylamide mono/di-lactate) interpolymers. Another aspect of this invention is the application of such temperature sensitive polymers as release systems of biologically active compounds. The polymers of the present invention comprise monomers, which have modifiable functionality. The functionality of the monomers can for example be modified by the presence of hydrolysable groups. The modification is effected by the incubation, leading to a change of the water solubility characteristics of the polymer. The polymers used in the present invention contain hydrolysable chemical groups. As a result the polymer's solution characteristics, specifically its lower critical solution temperature (LCST), change upon incubation. |
申请公布号 |
DE602005018489(D1) |
申请公布日期 |
2010.02.04 |
申请号 |
DE20056018489T |
申请日期 |
2005.03.17 |
申请人 |
UNIVERSITEIT VAN UTRECHT |
发明人 |
HENNINK, WILHELMUS EVERHARDUS;VAN NOSTRUM, CORNELIS FRANCISCUS;VAN STEENBERGEN, MARINUS JACOB;SOGA, OSAMU;RIJCKEN, CRISTIANNE JOHANNA FERDINAND |
分类号 |
C08F220/00;A61K9/107;A61K9/16;A61K9/22;A61K9/50;A61K9/51;C08F8/12;C08F20/58;C08F220/28;C08F220/54;C08F220/58 |
主分类号 |
C08F220/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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