发明名称 |
Stable liquid IL-1 antagonist formulations |
摘要 |
Formulations of an interleukin-1 (IL-1) antagonist are provided including a pre-lyophilized formulation, a reconstituted lyophilized formulation, and a stable liquid formulation. Preferably, the IL-1 antagonist is an IL-1 trap composed of a dimer of two fusion proteins having an amino acid sequence of SEQ ID NO: 10. Stable liquid formulations made with and without sodium chloride, and made with phosphate or histidine buffer, are provided.
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申请公布号 |
US7655758(B2) |
申请公布日期 |
2010.02.02 |
申请号 |
US20080048717 |
申请日期 |
2008.03.14 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
DIX DANIEL;BOWERS KATHERINE;GOOLCHARRAN CHIMANLALL;LIN LEU-FEN H. |
分类号 |
A61K36/20;A61K47/48;C07K14/475 |
主分类号 |
A61K36/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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