PREPARATIONS COMPRISING COMBINATIONS OF ENZYME INHIBITORS, AND THE USE THEREOF

摘要

The invention comprises a process wherein the DNA synthesis and, thus, the proliferation of mononuclear cells (MNZ) and of T cells as well is inhibited by the simultaneous and combined inhibition of the enzyme activity (I) of alanyl aminopeptidase and of dipeptidyl peptidase IV; (Ir) of dipeptidyl peptidase IV and of the angiotensin-converting enzyme; (III) of dipeptidyl peptidase IV and of prolyl oligopeptidase; and (IV) of di-peptidyl peptidase IV and of X-Pro-aminopeptidase to an extent which cann ot be achieved by an application of a single one of said enzyme inhibitors, even a t a higher dosage. Although the said inhibitors exercise an influence on the very same process finally, i.e. the DNA synthesis and, thus, the proliferation of immune cells , this effect is not complete and is not long lasting when a single inhibitor is applied. Fro m the functional overlap of enzymatic activities results an additive/superadditive inhibitory effect on the DNA synthesis and proliferation by the simultaneous inhibition of mor e than one of the above enzymes, as our data show. Our invention shows that the simultaneous application of substances inhibiti ng the above enzymes or of corresponding preparations and administration forms, respectively, is well suitable for a therapy of autoimmune diseases and chronic diseases with an inflammatory genesis as well as for a treatment of rejection episodes after a transplantation.