发明名称 |
T CELL ANTIGEN RECEPTOR PEPTIDES |
摘要 |
The present invention provides peptides which affect T-cells, presumably by action on the T-cell antigen receptor. The present invention further relates to the therapy of various inflammatory and autoimmune disease states involving the use of these peptides. Specifically, the peptides are useful in the treatment of disorders where T- cells are involved or recruited. In one aspect the peptides have the formula: R1-A-B-A-R2 in which A is a hydrophobic amino acid or a hydrophobic peptide sequence comprising between 2 and amino acids; B is a charged amino acid; R1 is NH2 and R2 is COOH. In another aspect the peptides have the formula: R1-A-B-C-R2 in which A is a peptide sequence of between 0 and 5 amino acids; B is cysteine; C is a peptide sequence of between 2 to 10 amino acids; R1 is NH2; and R2 is COOH.
|
申请公布号 |
CA2257973(C) |
申请公布日期 |
2010.02.02 |
申请号 |
CA19972257973 |
申请日期 |
1997.06.11 |
申请人 |
NORTHERN SYDNEY AREA HEALTH SERVICES |
发明人 |
MANOLIOS, NICHOLAS |
分类号 |
A61K38/00;C07K14/725;A61K31/00;A61K38/08;A61K38/10;A61K38/17;A61K47/48;A61P29/00;A61P37/00;A61P37/02;C07K4/00;C07K7/06;C07K7/08;C07K14/00 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|