| 摘要 |
<p>Disclosed is a process for the manufacture of a compound of formula (IV-a)
wherein PrG represents a hydroxyl-protecting group,
in which process 1,4-difluorobenzene is reacted in the presence of a base with a compound of formula (III-a)
wherein
PrG has the same meaning as in Formula (IV-a).
R 3 represents methyl or ethyl, and
R 4 represents methyl, ethyl or methoxy, or
R 3 and R 4 taken together with the nitrogen atom to which they are bound represent a 4- to 6-membered heterocyclic group having either no or one or two further heteroatoms selected from nitrogen or oxygen.</p> |
