Mutated amyloid protein

摘要

Provided is a human variant amyloid protein, which consists of a specified amino acid sequence comprising: (1) the 39 amino acids from position 597 to position 636 with the deletion of glutamic acid at position 618; (2) the 41 amino acids from position 597 to position 638 with the deletion of glutamic acid at position 618; or (3) the 42 amino acids from position 597 to position 639 with the deletion of glutamic acid at position 618. Further provided are corresponding DNAs, antibodies, transgenic animals having the protein, and uses of the composition in the manufacture of a medicament for vaccine therapy in amyloid disease.