发明名称 |
METHOD TO IMPROVE THE BIOLOGICAL AND ANTIVIRAL ACTIVITY OF PROTEASE INHIBITORS |
摘要 |
Methods for improving the cellular uptake of protease inhibitors (e.g., HIV protease inhibitor), alone or in the presence of one or more additional therapeutic agents, in protease inhibitor-based therapies, involving administration of one or more AAG-binding compounds, such as macrolide or lincosamide antibiotics, which have sufficient binding affinity for AAG to competitively bind AAG in the presence of the protease inhibitor.
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申请公布号 |
CA2230086(C) |
申请公布日期 |
2010.01.26 |
申请号 |
CA19962230086 |
申请日期 |
1996.08.30 |
申请人 |
UNIVERSITY OF ALABAMA AT BIRMINGHAM;SCHINAZI, RAYMOND F. |
发明人 |
SOMMADOSSI, JEAN-PIERRE;SCHINAZI, RAYMOND F. |
分类号 |
A61K31/70;A61K45/00;A61K31/00;A61K31/7048;A61K31/7056;A61K38/55;A61P31/04;A61P31/12;A61P31/18;A61P33/02;A61P35/00;A61P43/00 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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