| 摘要 |
Methods for using acoustic focusing technology on its own or in conjunction with hydrodynamic focusing for analyzing biological samples are provided. In one application, a preferential orientation of biological particles is achieved by applying a substantially elliptical acoustic field. In another application, a sample comprising a fluid medium carrying a plurality of discrete biological particles is pre-concentrated in-line with a sample analyzer, such as a flow cytometer, where a sheath fluid is introduced after acoustic pre-concentration. In a further application, methods for acoustically separating suspended discrete biological particles of different densities from a fluid medium are discussed. The particle-free fluid medium, such as a blood-cell-free and lipid-free clear serum, may be used for chemical analysis.
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