Methods for display of recombinant whole immunoglobulins or immunoglobulin libraries on the surface of eukaryote host cells, including yeast and filamentous fungi, are described. The methods are useful for screening libraries of recombinant immunoglobulins in eukaryote host cells to identify immunoglobulins that are specific for an antigen of interest.
申请公布号
WO2010005863(A1)
申请公布日期
2010.01.14
申请号
WO2009US49507
申请日期
2009.07.02
申请人
MERCK & CO., INC.;BIANKA, PRINZ;SETHURAMAN, NATARAJAN;ZHA, DONGXING;WILDT, STEFAN;BOBROWICZ, PIOTR
发明人
BIANKA, PRINZ;SETHURAMAN, NATARAJAN;ZHA, DONGXING;WILDT, STEFAN;BOBROWICZ, PIOTR