METHOD FOR PRODUCTION OF PLURIPOTENT STEM CELL

摘要

In the production of a cell mass containing a pluripotent stem cell, a step of treating a somatic cell under nutrient-starved conditions while contacting the somatic cell with a nuclear reprogramming factor and/or a step of treating the somatic cell with a substance capable of arresting a cell cycle is involved.  It becomes possible to induce and grow a pluripotent stem cell at high frequency, and it also becomes possible to produce a pluripotent stem cell with high efficiency.  The nuclear reprogramming factor to be used may be any one selected from the group consisting of OCT4, SOX2, c-MYC, KLF4, NANOG and LIN28.