COMPOSITIONS AND METHODS FOR DISCOVERING AGENTS FOR PHARMACOLOGICAL RESCUE OF HERG 1B SUBUNITS FOR THE TREATMENT OF LONG QT SYNDROME

摘要

Cells engineered to express a detectable hERG 1b polypeptide and methods for identifying agents that facilitate hERG 1b maturation using such cells are provided. A method for analyzing a biological sample for the presence of an amino acid substitution at position 8 of the hERG 1b N-terminus is further provided.