<p>A radioactive source wire having a distal end and a proximal end for local delivery of radiation to a target tissue is described. The source wire comprises: a relatively stiff proximal portion; a relatively flexible distal portion joined to the proximal portion; and a radioactive source secured to the distal end of the source wire. Also described is a device for local, directional delivery of radiation to intraocular target tissue that comprises the radioactive source wire.</p>