发明名称 |
N-HETEROCYCLIC CARBENE CATALYZED SYNTHESIS OF N-PHENYLISOXAZOLIDIN-5-ONE DERIVATIVE AND SYNTHESIS OF ß-AMINO ACID ESTER DERIVATIVE |
摘要 |
<p>A process for preparing a N-phenylisoxazolidin-5-one derivative is provided. The process for preparing the N-phenylisoxazolidin-5-one derivative comprises reacting anα,β-unsaturated aldehyde with nitrosobenzene in the presence of a N-heterocyclic carbene (NHC) catalyst. A process for preparing an N-alkoxyphenyl protectedβ-amino acid ester derivative is further provided. The process for preparing the N-alkoxyphenyl protectedβ-amino acid ester derivative comprises reacting anα,β-unsaturated aldehyde with nitrosobenzene in the presence of a N-heterocyclic carbene (NHC) catalyst to form a N-phenylisoxazolidin-5-one derivative, and then treating the N-phenylisoxazolidin-5-one derivative with an alcohol in the presence of an acid catalyst. A process for preparing an N-alkoxyphenyl protectedβ-amino acid ester derivative, comprising treating a N-phenylisoxazolidin-5-one derivative with an alcohol in the presence of an acid catalyst, is also provided.</p> |
申请公布号 |
EP2139873(A1) |
申请公布日期 |
2010.01.06 |
申请号 |
EP20080724343 |
申请日期 |
2008.03.14 |
申请人 |
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH |
发明人 |
ZHANG, YUGEN;YING, JACKIE Y.;SEAYAD, JAYASREE;PATRA, PRANAB, K. |
分类号 |
C07D261/04;C07C227/18;C07C229/18 |
主分类号 |
C07D261/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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