发明名称 |
APOPTOTIC AND ANTI-TUMOR ACTIVITIES OF METALLO-SALENS |
摘要 |
The present invention describes the synthesis and biochemical activities of metallo-salen compounds and their derivatives. The Mn(III)-salen and Fe(III)-salen derivatives of the present invention are potential anti-tumor agents, that affect cell viability, induce strong apoptotic activity, cause nuclear condensation, fragmentation, and ultimately death in breast cancer cells MCF-7.
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申请公布号 |
US2009326061(A1) |
申请公布日期 |
2009.12.31 |
申请号 |
US20090491103 |
申请日期 |
2009.06.24 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
MANDAL SUBHRANGSU S.;ANSARI KHAIRUL I.;GRANT, III JAMES D. |
分类号 |
A61K31/28;A61K31/295;A61P35/00;C07F13/00;C07F15/02 |
主分类号 |
A61K31/28 |
代理机构 |
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代理人 |
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地址 |
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