发明名称 |
4-(pyridin-4-yl)-1H-[1,3,5]triazin-2-one derivatives as GSK3-beta inhibitors for the treatment of neurodegenerative diseases |
摘要 |
A triazinone derivative represented by formula (I)
wherein:
Z represents a bond, a carbonyl group, a methylene group optionally substituted by one or two groups chosen from a C 1-6 alkyl group, a hydroxyl group, a C 1-6 alkoxy group; R1 represents a 4-pyridine ring; R2 represents a hydrogen atom, a C 1-6 alkyl; R3 represents a hydrogen atom, a C 1-6 alkyl group; R2 and R3 may form together a 6 membered cycle with the nitrogens caring R2 and R3 optionally substituted; R4 represents: a phenyl ring, being optionally substituted; n represents 0 to 2; in form of a free base or of an addition salt with an acid.
These compounds are useful as GSK3-² inhibitors.
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申请公布号 |
EP2138488(A1) |
申请公布日期 |
2009.12.30 |
申请号 |
EP20080290617 |
申请日期 |
2008.06.26 |
申请人 |
SANOFI-AVENTIS;MITSUBISHI TANABE PHARMA CORPORATION |
发明人 |
LOCHEAD, ALISTAIR;SAADY, MOURAD;YAICHE, PHILIPPE |
分类号 |
C07D401/04;A61K31/53;A61P3/10;A61P25/28;A61P33/06;A61P35/00;C07D487/04 |
主分类号 |
C07D401/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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