METHOD FOR PRODUCING INSULIN IN THE FORM OF AN ORAL PREPARATION

摘要

The invention relates to pharmacology and medicine, in particular to endocrinology. The inventive method consists in introducing insulin into a 1-50% aqueous solution of a polymer, the molar mass of which ranges from 0.4 to 40 kDa and which is pre-irradiated by an ionizing radiation dose of 1.0 to 5.0 Mrad, in such a way that the final concentration thereof ranges from 1 to 10 mg/ml at a ratio between polyethylene oxide and insulin equal to (1-500):1 and in agitating the mixture until a homogeneous transparent and slightly opalescent solution is obtained. Said method makes it possible to obtain a pharmaceutical composition comprising a biologically active insulin which exhibits a high hypoglycemic activity when enterally administered. The method provides simplification of oral insulin production and enhances therapeutic activity thereof.