CYCLOPEPTIDES CONTAINING RGD MIMETICS AS IMAGING MARKERS FOR INTEGRINS
摘要
Radiolabeled cyclic polypeptides, pharmaceutical compositions comprising radiolabeled cyclic polypeptides, and methods of using the radiolabeled cyclic polypeptides. Such polypeptides can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT). The radionuclide label is a positron or gamma emitter, e.g. 18F. The polypeptide core is a backbone cyclic RGD derivative of formula: (I) wherein R1 and R8 are side chains of natural or unnatural amino acids and w is an integer from 1 to 5.
申请公布号
WO2009134382(A3)
申请公布日期
2009.12.30
申请号
WO2009US02627
申请日期
2009.04.30
申请人
SIEMENS MEDICAL SOLUTIONS USA, INC.;KOLB, HARTMUTH, C.;CHEN, KAI;WALSH, JOSEPH, C.;LIANG, QIANWA