6-POSITION SUBSTITUTED INDOLINONES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS

摘要

The present invention relates to indolinones of general formula (see formula I) substituted in the 6 position, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof which have valuable pharmacological properties, especially an inhibitory effect on receptor tyrosine kinases and cyclin/CDK complexes, as well as on the proliferation of endothelial cells and various tumour cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.