DOSAGE FORMS AND METHODS FOR PROVIDING EFFECTIVE REBOXETINE THERAPY WITH ONCE-A-DAY DOSING

摘要

Dosage forms and methods for providing sustained release of reboxetine are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma reboxeti ne concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma reboxetine concentration occurrence in each 24 hour period. In addition, the peak plasma reboxetine concentration occurs at a later time following do se administration and exhibits a lesser magnitude than the peak plasma reboxetine concentration that occurs following administratio n of reboxetine in an immediate-release dosage form.