Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis

摘要

Use of a nucleic acid construct comprising (a) a cis regulatory element including a polynucleotide having the sequence set forth in SEQ ID NO:8 and at least one copy of the sequence as set forth in SEQ ID NO: 6; (b) an endothelial cell promoter; and (c) a polynucleotide sequence encoding a cytotoxic polypeptide comprising the extracellular region of TNFRI and the trans-membrane and intracellular regions of Fas cytotoxic polypeptide; for the manufacture of a medicament for inhibiting angiogenesis in a subject in need thereof; wherein said subject is being treated with an additional chemotherapeutic modality.