发明名称 |
REPORTER VECTOR FOR USE IN EVALUATION OF CYP1A2 INDUCTION |
摘要 |
A reporter vector which can evaluate the ability of a drug to induce CYP1A2 or both of CYP1A1 and CYP1A2 and a method for evaluation of the ability of a drug to induce CYP1A2 or both of CYP1A1 and CYP1A2 by using the reporter vector. A reporter system which can evaluate the ability of a drug capable of inducing CYP1A2 or both of CYP1A1 and CYP1A2 is completed by constructing a reporter vector having a reporter gene linked to the 3' end of a region between CYP1A1 and CYP1A2 or a reporter vector having different reporter genes linked to the both ends of the region, respectively, so as to sandwich the region, and a reporter vector having a deletion mutation in the region, and confirming that the expression of a reporter molecule is increased by the drug capable of inducing CYP1A2 or both of CYP1A1 and CYP1A2 in the reporter system using the reporter vector.
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申请公布号 |
US2009317800(A1) |
申请公布日期 |
2009.12.24 |
申请号 |
US20060995398 |
申请日期 |
2006.07.12 |
申请人 |
EISAI R&D MANAGEMENT CO., LTD.;TOHOKU UNIVERSITY |
发明人 |
UEDA RIKA;KUSANO KAZUTOMI;YAMAZOE YASUSHI;NAGATA KIYOSHI |
分类号 |
C12Q1/68;C12N5/00;C12N15/63 |
主分类号 |
C12Q1/68 |
代理机构 |
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