Pyridine derivatives of alkyl oxindoles as 5-HT7 receptor active agents

摘要

Disclosed are 3-alkyl indol-2-one derivatives of general Formula (I) which bind to 5-HT7 receptors and inhibit serotonin uptake, wherein R1 stands for hydrogen, halogen or alkyl; R2 and R3 represent hydrogen or alkyl; R4 represents hydrogen and R5 stands for a substituted phenyl moiety; or R4 and R5 form, together with the adjacent carbon atoms of the tetrahydropyridine ring, phenyl or a 5- or 6-membered heterocyclic ring containing sulphur as a heteroatom. Also disclosed is the use of an efficient amount of a pharmaceutical composition containing at least one of the above compounds or a pharmaceutically acceptable, organic or inorganic acid addition salt thereof for the manufacture of a medicament for the treatment or prophylaxis of central nervous system disorders, including depression, anxiety, compulsive disorder, panic disease, social phobia, schizophrenia, mood disorders, mania, mental decline, stroke, cell death in certain areas of the central nervous system, mental decline followed by cerebellar cell death, Alzheimer's disease, dementia, post-traumatic disease or stress disorder..