发明名称 |
OCULAR HYPOTENSIVE AGENT COMPRISING COMPOUND CAPABLE OF INHIBITING HISTONE DEACETYLASE AS ACTIVE INGREDIENT |
摘要 |
An object of the present invention is to find a novel pharmacological effect of a compound having an HDAC inhibitory effect. The compound having an HDAC inhibitory effect of the invention has an excellent effect of cell morphological change on trabecular meshwork cells and/or effect of intraocular pressure reduction, and is therefore useful as a preventive and/or therapeutic agent for a disease considered to be associated with aqueous humor circulation and/or intraocular pressure, particularly as a preventive and/or therapeutic agent for glaucoma or ocular hypertension.
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申请公布号 |
EP2135620(A1) |
申请公布日期 |
2009.12.23 |
申请号 |
EP20080739138 |
申请日期 |
2008.03.28 |
申请人 |
SANTEN PHARMACEUTICAL CO., LTD |
发明人 |
YONEDA, SHINJI;FUJISAWA, KOUSHI;WATANABE, KATSUHIKO;FUJIKAWA, JUNKO;SHIMAZAKI, ATSUSHI;KIRIHARA, TOMOKO;TAJIMA, HISASHI |
分类号 |
A61K45/00;A61K31/44;A61K31/443;A61K31/4433;A61K31/4436;A61K31/4439;A61K31/444;A61K31/5377;A61P27/02;A61P43/00;C07D213/81;C07D401/12;C07D405/12;C07D405/14;C07D409/12;C07D413/12;C07D417/12 |
主分类号 |
A61K45/00 |
代理机构 |
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主权项 |
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地址 |
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