发明名称 |
Nucleic acid and amino acid sequences encoding high-level expressor factor VIII polypeptides and methods of use |
摘要 |
Methods and compositions are provided that allow for high-level expression of a factor VIII polypeptide. More specifically, methods and compositions are provided comprising nucleic acid and amino acid sequences comprising a modified factor VIII that result in high-level expression of the polypeptide. The methods and compositions of the invention find use in the treatment of factor VIII deficiency including, for example, hemophilia A.
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申请公布号 |
US7635763(B2) |
申请公布日期 |
2009.12.22 |
申请号 |
US20040813507 |
申请日期 |
2004.03.30 |
申请人 |
EXPRESSION THERAPEUTICS, LLC. |
发明人 |
LOLLAR JOHN S. |
分类号 |
C07H21/02;C12N15/09;A61K38/00;A61K38/43;A61K48/00;A61P7/04;C07H21/04;C07K1/16;C07K14/755;C12N1/15;C12N1/19;C12N1/21;C12N5/02;C12N5/10;C12P19/34;C12P21/02;C12P21/06;C12Q1/68 |
主分类号 |
C07H21/02 |
代理机构 |
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代理人 |
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地址 |
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