USE OF INHIBITORS OF DIPEPTIDYL PEPTIDASE IV (DP IV) IN COMBINATION WITH INHIBITORS OF ALANYL-AMINOPEPTIDASE (APN)

摘要

The present invention relates to the use of inhibitors of dipeptidyl peptida se IV (DP IV) and of enzymes having the same substrate specifity (DP IV-analogous enzymatic activity) in combination with inhibitors of alanyl aminopeptidase (aminopeptidase N, APN) and of enzymes having the same substrate specifity (APN-analoguos enzymatic activity) for a more than additive to superadditive inhibition of the activation and proliferation (DNA synthesis) of human T lymphocytes and mononuclear cells and of the production of T H2 cytokines for a therapy and prevention o f allergic reactions of the type I according to the Gell and Coombs classification and for a more th an additive to superadditive inhibition of the activation, proliferation (DNA synthesis) of human epiderm al and follicular keratinocytes and of keratinocytes of the transitional zone between the skin and the mucous membranes as well as for a therapy and prevention of dermatological diseases with follicular and epidermal hyperkeratoses and an enhanced proliferation of keratinocytes. The invention also relates to the use of inhibitors of dipeptidyl peptidase IV (DP IV) as well as of enzymes having the same substrate specifity (DP IV-analogous enzymatic activity) in combination with inhibitor s of alanyl aminopeptidase (aminopeptidaseN, APN) and of enzymes having the same substrate specifity (APN-analogous enzymatic activity), respectively, of X-Pro-aminopeptidase (aminopeptidase P , APP), of the "angiotensin-converting enzyme" (ACE) and/or of the prolyl oligopeptidas e (POP, prolyl endopeptidase, PEP) for a more than additive to superadditive inhibition of activation, DNA synthesis and proliferation of human T lymphocytes and mononuclear cells for a therapy and prophylaxis of arteriosclerosis. The invention also relates to pharmaceutical preparations comprising more than one of said inhibitors of enzymes of the above group.