IMPROVEMENTS IN PLATINUM COMPOUNDS PREPARATION BY USE OF TETRABUTYLAMMOUNIUM AMMINETRICHLOROPLATINATE AS INTERMEDIATE

摘要

The invention provides a commercially practicable route to X[PtCl 3 (NH 3 )], where X represents an alkali metal ion, comprising the steps of heating a reaction mixture comprising cisplatin in an acidified organic solvent, together with NBu 4 OH, a Pt catalyst and saturated aqueous NaC1 solution to form (NBu 4 )[PtCl 3 (NH 3 )], and reacting that product with an alkali metal salt, to form X[PtCl 3 (NH 3 )] The product may be used in the synthesis of platinum anticancer complexes.