发明名称 |
BLOCK CO-POLYPEPTIDE AND HYDROGELS MADE THEREOF |
摘要 |
<p>Disclosed is a block co-polypeptide comprising at least two blocks T and at least one block S, with blocks T and S alternating, wherein each T independently denotes a Trimerizing Block being a polypeptide block capable of forming a thermoreversible collagen-like triple helix structure, and whereineach S independently denotes a Spacer Block S being a polypeptide neither forming a collagen-like triple helix. The block co-polypeptide is capable of forming a gel, and is useful as an animal-free, biocompatible substitute for gelatin. Uniquely, the polypeptide allows the independent controlling of the melting temperature of the gel, the stiffness and crosslink density of the gel, the lower critical gel-forming concentration related to the length of the molecules, and unrelated (e.g. biological, physiological, pharmaceutical or signalling) functions of the molecule.</p> |
申请公布号 |
WO2009151327(A1) |
申请公布日期 |
2009.12.17 |
申请号 |
WO2009NL50327 |
申请日期 |
2009.06.11 |
申请人 |
STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK;DE WOLF, FREDERIK ANTON;WERTEN, MARC WILLEM THEODOOR;MOERS, ANTONIUS PETRUS HENDRICUS ANNA;WOLBERT, EMIL JOHAN HARALD;EGGINK, GERRIT |
发明人 |
DE WOLF, FREDERIK ANTON;WERTEN, MARC WILLEM THEODOOR;MOERS, ANTONIUS PETRUS HENDRICUS ANNA;WOLBERT, EMIL JOHAN HARALD;EGGINK, GERRIT |
分类号 |
C07K14/78 |
主分类号 |
C07K14/78 |
代理机构 |
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代理人 |
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地址 |
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