METHOD FOR PREPARING DIFFERENTIATED AVIAN CELLS AND GENES INVOLVED IN MAINTAINING PLURIPOTENCY

摘要

The present invention relates to a method for preparing differentiated avian cells from stem cells in culture. Genes involved in maintaining the pluripotency of avian stem cells were identified and cloned. By inhibiting the expression of these genes in stem cells, the latter lose their pluripotency characteristics and enter into differentiation. These differentiated cells obtained in vitro can serve as host cells for pathogens, in particular viruses, and can thus be used for the production of antiviral vaccines.