<p>Methods of forming compositions for the sustained release of water soluble active agents, including biologically active polypeptides and products produced by the process are described. Improved product characteristics and ease of scale-up can be achieved using a novel coacervation process wherein at least one coacervation agent is added to the mixture comprising the active agent and the polymer in at least two distinct stages.</p>
申请公布号
EP2131815(A1)
申请公布日期
2009.12.16
申请号
EP20080732476
申请日期
2008.03.19
申请人
ALKERMES, INC.
发明人
KUMAR, RAJESH;TROIANO, GREGORY;RAMSTACK, J., MICHAEL;HERBERT, PAUL;FIGA, MICHAEL