COMPOUNDS HAVING AN ANTAGONISTIC ACTIVITY ON HISTAMINE H3 RECEPTOR AND THE PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS CONTAINING THE SAME

摘要

PURPOSE: A pharmaceutical composition for preventing and treating narcolepsy, congnitive disorder, ADHD(attention-deficit hyperactivity disorder), obesity, epilepsy, schizophrenia, depression, and pain. CONSTITUTION: A pharmaceutical composition for preventing and treating central nervous system disease contains a compound having histamine H3 receptor antagonism. The compound is 4-[3-methyl-3-(1-methyl-pyperidine-4-yl)-ureido]-benzoic acid ethyl ester of chemical formula 1, 1-benzyloxy-3-(4-pyridine-2-yl-piperazine-1-yl)-propan-2-ol of chemical formula 2, N-{4-[4-(2-bromo-4-fluoro-phenyutiocarbamoyl)-[1,4]diazepan-1-yl-methyl]-phenyl}-aceteamide of chemical formula 3, 2-[4-(5-bromo-2H-1λ4-thiophene-2-carbonyl)-[1,4]diazepan-1-yl]-N-phenethyl-aceteamide of chemical formula 4. 1-[benzyl-(2,2-diethoxy-ethyl)-amino]-3-(4-chloro-phenoxy)-propan-2-ol of chemical formula 5, and 5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonic acid-[2-(1-benzyl-piperidine-4-yl) ethyl]-amide of chemical formula 6.