POLYNUCLEOTIDES AND CHIMAERA POLYPEPTIDES FOR RELEASING A POLYPEPTIDE OF INTEREST COMBINED WITH EXOSOMES AND USE THEREOF FOR THE PRODUCTION OF IMMUNOGENIC COMPOSITIONS

摘要

The invention relates to a chimaera polypeptide that comprises a plurality of polypeptide domains and that can be released in association with membrane vesicles and in particular exosomes. The invention also relates to a polypeptide comprising one of said domains for releasing a peptide or polypeptide of interest in association with membrane vesicles and in particular exosomes. The invention also relates to the use of the polypeptides of the invention and of polynucleotides coding for said polypeptides for producing immunogenic compositions containing exosomes or DNA or for screening proteic interactions. The invention also relates to the implementation of the properties of exosomes including a polypeptide of the invention, and of immunogenic compositions of the invention for preventing and/or treating an infection due to a pathogen agent, a pathogen organism, a tumoral antigen or a cytoplasmic antigen, in particular for eliciting or promoting in vivo in a host, particularly a human or non-human mammal or a bird, a humoral and/or cellular response against a virus, a bacteria, a parasite or a tumour.