Anti-viral nucleoside analogs and methods for treating viral infections, especially HIV infections

摘要

The present invention relates to novel compounds according to the general Formulae (I, II, III, IV or V); wherein B is nucleoside base according to the structure Formula (VI); R is H, F, Cl, Br, I, C 1 -C 4 alkyl (preferably CH 3 ), -C‰¡N, -C‰¡C-R a , Formula (VII); X is H, C 1 -C 4 alkyl (preferably CH 3 ), F,Cl,Br or 1; Z is 0 or CH 2 with the proviso that Z is CH 2 and not O when the compound is according to general formula II, R 3 is -C‰¡C-H and R 2 is H or a phosphate, diphosphate, triphosphate or phosphotriester group; R 1 is H, an acyl group, a C 1 -C 20 alkyl or an ether group; R2 is H, an acyl group, a CI-C20 alkyl or ether group, a phosphate, diphosphate, triphosphate, phosphodiester group or a Formula; (VIII) or Formula (IX) group; Nu is a radical of a biologically active antiviral compound such that an amino group or hydroxyl group from said biologically active antiviral compound forms a phosphate, phosphoramidate, carbonate or urethane group with the adjacent moiety; R8 is H, or a C1-C20 alkyl or ether group, preferably a C1-C12 alkyl group; k is 0-12, preferably, 0-2; R3 is selected from a C1-C4 alkyl (preferably CH3), -(CH2)n-C=C-Ra, Formula (X) or Formula (XI); R3a and R3b are independently selected from H, F, C1, Br or I; R4 and R5 are independently selected from H, F, Cl, Br, I, OH, C1-C4 alkyl (preferably CH3),-(CH2)n-C‰¡C-Ra, Formula (XII) or Formula (XIII) with the proviso that R4 and R5 are not both H; Ra is H,F,Cl,Br,I or -C1-C4 alkyl, preferably H or CH3; Y is H, F, C1, Br, I or -C1-C4 alkyl, preferably H or CH3; and n is 0,1,2,3,4 or 5, preferably 0, 1 or 2; and their anomers, pharmaceutically acceptable salts, solvates or polymorphs thereof.