发明名称 |
STABLE PHARMACEUTICAL SOLUTION FORMULATION FOR PRESSURIZED METERED DOSE INHALERS |
摘要 |
Aerosol solution formulations for use in an aerosol inhaler which comprise 8-hydroxy-5-[(1R)-1-hydroxy-2-1[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone or a salt thereof, in particular the hydrochloride salt (ТА 2005), as an active ingredient, a propellant containing a hydrofluoroalkane, and a cosolvent, stabilized by addition of a specific small amount of a high concentrated phosphoric acid and optionally by the use of a suitable can having part or all of its internal metallic surfaces lined with an inert organic coating. |
申请公布号 |
UA88894(C2) |
申请公布日期 |
2009.12.10 |
申请号 |
UA20060008865 |
申请日期 |
2005.02.25 |
申请人 |
CHIESI FARMACEUTICI S.P.A. |
发明人 |
LEWIS DAVID;GANDERTON DAVID;MEAKIN BRIAN;DELCANALE MAURIZIO;PIVETTI FAUSTO |
分类号 |
A61K9/12;A61K31/4704;B65D83/14 |
主分类号 |
A61K9/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|