| 摘要 |
A (bio-)chemical assay on sensing objects (4) e.g. for use as a drug screening assay on living cells, as well uses and a method for making such an integrated system is proposed. The assay is comprising a base element (1) with on a surface an array of multiple immobilisation points (5) for individual sensing objects such as cells (4) or groups of a few sensing objects, and a flow chamber (8) bordered on a first lateral side by said base element (1) and covering said base element (1) at least in the region with the array of immobilisation points (5), wherein the flow chamber (8) on an entry-side comprises at least one or two inlets (17) for the introduction of different test solutions into the flow chamber (8) in a flow direction (20), and on an exit-side located opposite to the entry-side comprises at least one outlet (10) for the test solutions, wherein these inlets (17) are located substantially in a plane parallel to the surface of the base element (1) and spaced apart in a direction perpendicular to the flow direction (20) of the test solutions such that the test solutions flow across over the array of multiple immobilisation points (5) and sensing objects (4) located thereon in a parallel laminar flow, such that there is no interference and/or or well-defined and reproducible interference between the flow of the different test solutions over defined groups of the array of multiple immobilisation points (5).
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