NEW ISOINDOLE DERIVATIVES, COMPOSITIONS CONTAINING THEREOF, PRODUCTION AND PHARMACEUTICAL APPLICATION THEREOF, PARTICULARLY AS INHIBITORS OF CHAPERONE PROTEIN Hsp90 ACTIVITY

摘要

FIELD: medicine. ^ SUBSTANCE: there are described new isoindole derivatives of general formula (1), wherein A1, A2 and A4 stands for CH, and A3 means N or C-OH; n is equal to 2; R1 represents O; R2-stands for H; and a pharmaceutical composition containing thereof. ^ EFFECT: new compounds are inhibitors of chaperone protein Hsp90 activity and can be used in chemotherapy of cancerous diseases. ^ 6 cl, 3 ex