NEUROINVASION INHIBITOR

摘要

It is found that neuroinvasion in a neuroinvasion model for pancreatic cancer can be inhibited by inhibiting IL-6.  Further, it is demonstrated that an IL-6 receptor is expressed in a human pancreatic cancer cell line and IL-6 can increase the chemotactic ability, the migratory ability and the intercellular signaling of a pancreatic cancer cell, and it is found that pancreatic cancer can be treated by inhibiting IL-6.  Still further, it is found that human pancreatic cancer neuroinvasion can be inhibited by administering an IL-6 inhibitor to a mouse neuroinvasion model.