发明名称 |
Evolution of whole cells and organisms by recursive sequence recombination |
摘要 |
The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
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申请公布号 |
US7629170(B2) |
申请公布日期 |
2009.12.08 |
申请号 |
US20060506215 |
申请日期 |
2006.08.17 |
申请人 |
MAXYGEN, INC. |
发明人 |
DELCARDAYRE STEPHEN;TOBIN MATTHEW B.;STEMMER WILLEM P. C.;NESS JON E.;MINSHULL JEREMY S.;PATTEN PHILLIP A.;SUBRAMANIAN VENKITESWATAN MANI;CASTLE LINDA A.;KREBBER CLAUS M.;BASS STEVEN H.;ZHANG YING-XIN;COX ANTHONY R.;HUISMAN GJALT W.;YUAN LING;AFFHOLTER JOSEPH A. |
分类号 |
C12N15/00;C07K14/245;C12N15/10;C12N15/63;C12N15/82;C12N15/87;C12P17/16;C12Q1/68 |
主分类号 |
C12N15/00 |
代理机构 |
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