发明名称 |
Methods for making proteins containing free cysteine residues |
摘要 |
The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent. The soluble proteins produced by the methods can then be modified to increase their effectiveness. Such modifications include attaching a PEG moiety to form pegylated proteins.
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申请公布号 |
US7629314(B2) |
申请公布日期 |
2009.12.08 |
申请号 |
US20040857644 |
申请日期 |
2004.05.27 |
申请人 |
BOLDER BIOTECHNOLOGY, INC. |
发明人 |
COX, III GEORGE N. |
分类号 |
A61K38/18;A61K47/48;C07K1/113;C07K14/505;C07K14/56;C07K14/61;C07K14/72;C12P21/02 |
主分类号 |
A61K38/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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