MICROORGANISM OPTIMIZED FOR SECRETION

摘要

Proteins which comprise a cofactor can be secreted in an improved manner in a microorganism which belongs to the genus Corynebacterium provided that the microorganism contains a nucleic acid sequence which is not naturally present in this and which comprises at least the following sequence sections: a) nucleic acid sequence coding for a protein which contains a cofactor, and b) a nucleic acid sequence which is at least 20% identical to the sequence given in SEQ ID NO. 1 or a nucleic acid sequence which is a structural homologue to this sequence, wherein the amino acid sequence which is encoded by the nucleic acid sequence b) functionally interacts with the amino acid sequence encoded by the nucleic acid sequence a) in such a manner that at least the amino acid sequence encoded by the nucleic acid sequence a) is excreted by the microorganism.