发明名称 Indoles having anti-diabetic activity
摘要 Indoles of Formula I having -X-aryl-(CH2)x-oxazolidinedione and -X-heteroaryl-(CH2)x-oxazolidinedione substituents on the N atom of the indole ring, where x is 0 or 1, and -X- is a bond or -CH2-, and their thiazolidinedione analogs, are PPAR gamma agonists or partial agonists and are useful in the treatment and control of type II diabetes, including hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.
申请公布号 US7625933(B2) 申请公布日期 2009.12.01
申请号 US20050631465 申请日期 2005.06.28
申请人 MERCK & CO., INC. 发明人 LIU KUN;MEINKE PETER T.;WOOD HAROLD B.
分类号 A61K31/422;C07D263/04;C07D413/10 主分类号 A61K31/422
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