发明名称 |
Determining the risk of human anti-human antibodies in transgenic mice |
摘要 |
The present embodiments relate to methods of identifying and creating human or humanized antibodies that possess a reduced risk of inducing a Human Anti-Human Antibody (HAHA) response when they are applied to a human host. Other methods are directed to predicting the likelihood of a HAHA response occurring. Methods for screening for anti-HAHA compounds are also included. Methods for determining if various conditions for administering an antibody to a subject enhance or suppress a HAHA response are also included. |
申请公布号 |
US7625549(B2) |
申请公布日期 |
2009.12.01 |
申请号 |
US20050136250 |
申请日期 |
2005.05.23 |
申请人 |
AMGEN FREMONT INC. |
发明人 |
KELLERMANN SIRID-AIMEE;GREEN LARRY L.;KORVER WOUTER |
分类号 |
A61K49/00;A01K67/00;A01K67/027;C07K16/46;G01N33/53 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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