CYCLOPROPYL GROUP SUBSTITUTED OXAZOLIDINONE ANTIBIOTICS AND DERIVATIVES THEREOF

摘要

THIS INVENTION RELATES TO NEW OXAZOLIDINONES HAVING A CYCLOPROPYL MOIETY, WHICH ARE EFFECTIVE AGAINST AEROBIC AND ANEROBIC PATHOGENS SUCH AS MULTI-RESISTANT STAPHYLOCOCCI, STREPTOCOCCI AND ENTEROCOCCI, BACTEROIDES SPP., CLOSTRIDIA SPP.SPECIES, AS WELL AS ACID-FAST ORGANISMS SUCH AS MYCOBACTERIUM TUBERCULOSIS AND OTHER MYCOBACTERIAL SPECIES.THE COMPOUNDS ARE REPRESENTED BY STRUCTURAL FORMULA I: ITS ENANTIOMER, DIASTEREOMER,OR PHARMACEUTICALLY ACCEPTABLE SALT OR ESTER THEREOF.