Antibody or fragment thereof which binds human Nogo-A epitope with enhanced affinity and pharmaceutical use thereof

摘要

Disclosed is an antibody or fragment thereof which binds the human NogoA 324-357 epitope defined by amino acid sequence ELPTALTKLV with a dissociation constant (Kd) < 1000 nM. Further disclosed is an antibody or fragment thereof for the treatment of disorders associated with nerve repair.