发明名称 |
Azacyclohexane Derivatives as Inhibitors of Stearoyl-Coenzyme a Delta-9 Desaturase |
摘要 |
Azacyclohexane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
|
申请公布号 |
US2009291955(A1) |
申请公布日期 |
2009.11.26 |
申请号 |
US20060083928 |
申请日期 |
2006.11.10 |
申请人 |
CRANE SHELDON N;ROBICHAUD JOEL STEPHANE;LEGER SERGE;RAMTOHUL YEEMAN K |
发明人 |
CRANE SHELDON N.;ROBICHAUD JOEL STEPHANE;LEGER SERGE;RAMTOHUL YEEMAN K. |
分类号 |
A61K31/53;A61K31/4365;A61K31/519;A61P3/10;C07D513/04 |
主分类号 |
A61K31/53 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|