发明名称 |
METHODS FOR PREDICTING ESOPHAGEAL ADENOCARCINOMA (EAC) |
摘要 |
This invention relates, e.g., to methods for predicting a subject's risk for developing esophageal adenocarcinoma (EAC) or high-grade dysplasia (HGD), comprising determining in a sample from the subject the methylation levels of transcriptional promoter regions of various combinations of, among other genes, (a) cadherin 13, H-cadherin (heart) (CDH13); (b) tachykinin-1 (TAC1); (c) nel-like 1 (NELL1); (d) A-kinase anchoring protein 12 (AKAP12); (e) somatostatin (SST); (f) transmembrane protein with EGF-like and two follistatin-like domains (HPP1); (g) CDKN2a, cyclin-dependent kinase inhibitor 2a (p16); or (h) runt-related transcription factor 3 (RUNX3).
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申请公布号 |
WO2009105533(A3) |
申请公布日期 |
2009.11.26 |
申请号 |
WO2009US34508 |
申请日期 |
2009.02.19 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY;MELTZER, STEPHEN J.;CHENG, YULAN;JIN, ZHE |
发明人 |
MELTZER, STEPHEN J.;CHENG, YULAN;JIN, ZHE |
分类号 |
C12Q1/68;G01N33/574 |
主分类号 |
C12Q1/68 |
代理机构 |
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地址 |
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