| 发明名称 |
AI-2 compounds and analogs based on Salmonella typhimurium LsrB structure |
| 摘要 |
This invention relates to crystals comprising apo-LsrB and holo-LsrB. The structure of holo-LsrB identifies a tetrahydroxytetrahydrofuran derived from 4,5-dihydroxy-2,3-pentanedione (DPD) as the active autoinducer-2 (AI-2) molecule in Salmonella typhimurium. The X-ray crystallographic data can be used in a drug discovery method. Additionally the invention provides AI-2 analogs based on this discovery as well as pharmaceutical compositions containing those analogs.
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| 申请公布号 |
US2009286873(A1) |
申请公布日期 |
2009.11.19 |
| 申请号 |
US20090381572 |
申请日期 |
2009.03.13 |
| 申请人 |
THE TRUSTEES OF PRINCETON UNIVERSITY |
发明人 |
MILLER STEPHEN T.;XAVIER KARINA B.;TAGA MICHIKO E.;CAMPAGNA SHAWN R.;SEMMELHACK MARTIN F.;BASSLER BONNIE L.;HUGHSON FREDERICK M. |
| 分类号 |
A61K31/341;A61K38/00;A61P33/04;C07D307/04;C07K14/255 |
主分类号 |
A61K31/341 |
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