| 摘要 |
<p>The invention relates to a method for preparing an aqueous suspension of nanocapsules comprising an oily core surrounded by a polymeric envelope. According to said method, the following phases are mixed: a) a first phase, called an oily phase, comprising a hydrophobic polymer, an oil or a mixture of oils, at least one active principle, and a surfactant TA1, said oily phase being brought to a temperature T1 higher than the melting temperature of the hydrophobic polymer, the hydrophobic polymer being miscible, at said temperature T1, with the mixture of the surfactant TA1 and oil, or mixture of oils, and the active principle being miscible, soluble or solubilised in the mixture of the surfactant TA1 and oil, or mixture of oils; and b) a second phase, called a polar phase, comprising a hydrophilic polymer in the form of a hydrogel in an aqueous solution containing a surfactant TA2, in such a way as to obtain the formation of the nanocapsules in an aqueous suspension.</p> |
