| 发明名称 |
ASSAYS FOR MODULATORS OF ASPARAGINYL HYDROXYLASE |
| 摘要 |
The present invention is directed to methods of identifying an agent which modulates hydroxylation of hypoxia inducible factor (HIF), comprising contacting a HIF asparagine hydroxylase and a test substance in the presence of a substrate of the hydroxylase under conditions in which asparagine in the substrate is hydroxylated in the absence of the test substance; and determining hydroxylation of the substrate.
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| 申请公布号 |
US2009286858(A1) |
申请公布日期 |
2009.11.19 |
| 申请号 |
US20090433607 |
申请日期 |
2009.04.30 |
| 申请人 |
ISIS INNOVATION LIMITED |
发明人 |
PUGH CHRISTOPHER WILLIAM;GLEADLE JONATHAN MARK;RATCLIFFE PETER JOHN;SCHOFIELD CHRISTOPHER JOSEPH;MCNEILL LUKE ALEXANDER |
| 分类号 |
A61K31/7088;G01N33/50;A61K38/43;A61K45/00;A61K48/00;A61P3/10;A61P9/10;A61P9/12;A61P17/02;A61P29/00;A61P35/00;A61P37/06;A61P43/00;C12N5/06;C12N9/02;C12N9/99;C12N15/09;C12Q1/26;G01N33/15;G01N33/68 |
主分类号 |
A61K31/7088 |
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