| 摘要 |
The present invention relates to a thiazepine derivative or a pharmacologically acceptable salt thereof having an excellent effect of inhibiting 11²-hydroxysteroid dehydrogenase type 1. A thiazepine derivative or a pharmacologically acceptable salt thereof having general formula (I):
wherein
R 1 represents a hydrogen atom, a C 1 -C 6 alkyl group or the like; R 2 represents a C 1 -C 6 alkyl group, a C 1 -C 6 halogenated alkyl group, a C 1 -C 6 hydroxyalkyl group, or the like; R 3 represents a hydrogen atom or a C 1 -C 6 alkyl group; R 4 represents a C 6 -C 10 aryl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group a or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group a; Substituent Group a consists of a halogen atom, a C 1 -C 6 alkyl group, a C 6 -C 10 aryl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group b, and so forth; Substituent Group b consists of a halogen atom, a C 1 -C 6 alkyl group, a C 1 -C 6 halogenated alkyl group, and so forth.
|
