| 发明名称 |
Manipulation of cytokine levels using CD83 gene products |
| 摘要 |
The invention provides methods for modulating cytokine levels, GM-CSF levels and the immune system using CD83 nucleic acids, CD83 polypeptides, anti-CD83 antibodies and factors that influence CD83 activity or expression. The invention also provides mice having a mutant CD83 gene and mice having a transgenic CD83 gene, which are useful for defining the role of CD83 in the immune system and for identifying compounds that can modulate CD83 and the immune system. |
| 申请公布号 |
US7618629(B2) |
申请公布日期 |
2009.11.17 |
| 申请号 |
US20050496284 |
申请日期 |
2005.09.30 |
| 申请人 |
CELLTECH R&D, INC. |
发明人 |
RAMSDELL FRED;PROLL SEAN C.;STAEHLING-HAMPTON KAREN;APPLEBY MARK W.;GARCIA-MARTINEZ LEON FERNANDO |
| 分类号 |
A01K67/027;A61K39/40;A61K31/7088;A61K38/00;A61K38/17;A61K39/395;A61K48/00;A61P1/04;A61P1/16;A61P3/10;A61P7/00;A61P11/06;A61P13/12;A61P15/02;A61P17/00;A61P17/06;A61P17/14;A61P19/02;A61P21/04;A61P25/00;A61P27/14;A61P27/16;A61P29/00;A61P31/00;A61P31/04;A61P31/06;A61P31/12;A61P31/14;A61P31/16;A61P31/18;A61P31/22;A61P33/02;A61P33/10;A61P35/00;A61P37/06;A61P37/08;A61P43/00;C07K14/705;C07K16/00;C07K16/18;C07K16/28;C07K16/30;C12N5/10;C12N15/09;C12N15/11;C12P21/02;C12P21/08;C12Q1/02 |
主分类号 |
A01K67/027 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
